Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Park SK, Qi XF, Song SB, Kim DH, Teng YC, Yoon YS, Kim KY, Li JH, Jin D, Lee KJ.
Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon, Republic of Korea.

Abstract

Ethanol consumption disturbs the balance between the pro- and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia for drinking purposes because of its therapeutic properties including scavenging effect of reactive oxygen species. This study was performed to investigate the effect of ERW on acute ethanol-induced hangovers in Sprague-Dawley rats. Alcohol concentration in serum of ERW-treated rats showed significant difference at 1 h, 3 h and 5 h respectively as compared with the rats treated with distilled water. Both alcohol dehydrogenase type 1 and acetaldehyde dehydrogenase related with oxidation of alcohol were significantly increased in liver tissue while the level of aspartate aminotransferase and alanine aminotransferase in serum was markedly decreased 24 h after pre-oral administration of ERW. Moreover, oral administration of ERW significantly activated non-ezymatic (glutathione) and enzymatic (glutathione peroxidase, glutathione-S-transferase, Cu/Zn-superoxide dismutase and catalase) antioxidants in liver tissues compared with the control group. These results suggest that drinking ERW has an effect of alcohol detoxification by antioxidant mechanism and has potentiality for relief of ethanol-induced hangover symptoms.

PMID: 19887722 [PubMed - indexed for MEDLINE]
Food Chem Toxicol. 2009 Aug;47(8):2031-6. Epub 2009 May 27.

Editor’s note: The Japanese have long used ionized alkaline water from a water ionizer prevent and provide relief of hangovers. For best results, try drinking a glass or two of ionized alkaline water before bed after a night of drinking as well as upon rising. You can also try diluting each glass of alcohol with ionized alkaline water or or ice cubes made with ionized alkaline water. See our other tips on ways to enhance beverages with ionized alkaline water.

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