Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice

Mi-Ja Kim(a), Hye Kyung Kim(b)
(a) Department of Obesity management, Graduate School of Obesity Science, Dongduk Women’s University, 23-1 Wolkgukdong, Seoul, 136-714, South Korea
(b) Department of Food and Biotechnology, Hanseo University, Sesan, 356-706, South Korea

Received 28 February 2006; Accepted 27 July 2006. Available online 2 August 2006.

Abstract:

Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic β-cell dysfunction found in diabetes. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in two different diabetic animal models. The genetically diabetic mouse strain C57BL/6J-db/db (db/db) and streptozotocin (STZ)-induced diabetic mouse were used as insulin deficient type 1 and insulin resistant type 2 animal model, respectively. ERW, provided as a drinking water, significantly reduced the blood glucose concentration and improved glucose tolerance in both animal models. However, ERW fail to affect blood insulin levels in STZ-diabetic mice whereas blood insulin level was markedly increased in genetically diabetic db/db mice. This improved blood glucose control could result from enhanced insulin sensitivity, as well as increased insulin release. The present data suggest that ERW may function as an orally effective anti-diabetic agent and merit further studies on its precise mechanism.

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